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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 1
2004 5
2005 6
2006 2
2007 6
2008 7
2009 6
2010 10
2011 11
2012 19
2013 19
2014 13
2015 13
2016 16
2017 19
2018 10
2019 13
2020 23
2021 21
2022 16
2023 8
2024 4

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220 results

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Page 1
Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization.
Vergadi E, Ieronymaki E, Lyroni K, Vaporidi K, Tsatsanis C. Vergadi E, et al. J Immunol. 2017 Feb 1;198(3):1006-1014. doi: 10.4049/jimmunol.1601515. J Immunol. 2017. PMID: 28115590 Review.
Depending on the signals, macrophages obtain an array of activation phenotypes, described by the broad terms of M1 or M2 phenotype. The PI3K/Akt/mTOR pathway mediates signals from multiple receptors including insulin receptors, pathogen-associated molecular pattern recepto …
Depending on the signals, macrophages obtain an array of activation phenotypes, described by the broad terms of M1 or M2 phenotype. The PI3K …
"The emerging role of capivasertib in breast cancer".
Andrikopoulou A, Chatzinikolaou S, Panourgias E, Kaparelou M, Liontos M, Dimopoulos MA, Zagouri F. Andrikopoulou A, et al. Breast. 2022 Jun;63:157-167. doi: 10.1016/j.breast.2022.03.018. Epub 2022 Apr 1. Breast. 2022. PMID: 35398754 Free PMC article. Review.
Over 50% of breast tumors harbor alterations in one or more genes of the phosphatidylinositol 3-kinase (PI3K) pathway including PIK3CA mutations (31%), PTEN loss (34%), PTEN mutations (5%) and AKT1 mutations (3%). While PI3K and mTOR inhibitors are already approved in adva …
Over 50% of breast tumors harbor alterations in one or more genes of the phosphatidylinositol 3-kinase (PI3K) pathway including PIK3CA mutat …
PKBbeta/AKT2 deficiency impacts brain mTOR signaling, prefrontal cortical physiology, hippocampal plasticity and select murine behaviors.
Palumbo S, Paterson C, Yang F, Hood VL, Law AJ. Palumbo S, et al. Mol Psychiatry. 2021 Feb;26(2):411-428. doi: 10.1038/s41380-020-00964-4. Epub 2020 Dec 16. Mol Psychiatry. 2021. PMID: 33328589 Free PMC article.
Reduced sensitivity to amphetamine was observed, supporting a role for Akt2 in regulating dopaminergic tone. Biochemical analyses revealed dysregulated brain mTOR and GSK3beta signaling, consistent with observed learning and memory impairments. Rescue of cognitive i …
Reduced sensitivity to amphetamine was observed, supporting a role for Akt2 in regulating dopaminergic tone. Biochemical analyses rev …
Akt2 causes TGFbeta-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression.
Das F, Ghosh-Choudhury N, Lee DY, Gorin Y, Kasinath BS, Choudhury GG. Das F, et al. PLoS One. 2018 Nov 16;13(11):e0207285. doi: 10.1371/journal.pone.0207285. eCollection 2018. PLoS One. 2018. PMID: 30444896 Free PMC article.
TGFbeta time-dependently increased the activating phosphorylation of Akt2. Expression of dominant negative PI 3 kinase and its signaling inhibitor PTEN blocked Akt2 phosphorylation by TGFbeta. Inhibition of Akt2 using a phospho-deficient mutant that inactivat …
TGFbeta time-dependently increased the activating phosphorylation of Akt2. Expression of dominant negative PI 3 kinase and its signal …
Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice.
Sasako T, Umehara T, Soeda K, Kaneko K, Suzuki M, Kobayashi N, Okazaki Y, Tamura-Nakano M, Chiba T, Accili D, Kahn CR, Noda T, Asahara H, Yamauchi T, Kadowaki T, Ueki K. Sasako T, et al. Nat Commun. 2022 Oct 5;13(1):5655. doi: 10.1038/s41467-022-33008-2. Nat Commun. 2022. PMID: 36198696 Free PMC article.
These phenotypes are almost reversed by additional knocking out of Foxo1/4, but only partially by additional knocking out of Tsc2 to activate the mTOR pathway. Overall, our data suggest that, unlike in lower organisms, suppression of Akt activity in skeletal muscle of mamm …
These phenotypes are almost reversed by additional knocking out of Foxo1/4, but only partially by additional knocking out of Tsc2 to activat …
Circular RNA nuclear receptor interacting protein 1 promoted biliary tract cancer epithelial-mesenchymal transition and stemness by regulating the miR-515-5p/AKT2 axis and PI3K/AKT/mTOR signaling pathway.
Gao X, Yu S, Liu S, Zhang S, Sha X, Sun D, Jiang X. Gao X, et al. Environ Toxicol. 2023 Nov;38(11):2632-2644. doi: 10.1002/tox.23898. Epub 2023 Jul 19. Environ Toxicol. 2023. PMID: 37466171
Mechanically, we revealed that circ_NRIP1 served as the competing endogenous RNA to sequester miR-515-5p through complementary base pairing mechanism, thereby upregulated AKT2 expression and indirectly activated PI3K/AKT/mTOR signaling pathway. Generally, targeting …
Mechanically, we revealed that circ_NRIP1 served as the competing endogenous RNA to sequester miR-515-5p through complementary base pairing …
Sirt1 decreased adipose inflammation by interacting with Akt2 and inhibiting mTOR/S6K1 pathway in mice.
Liu Z, Gan L, Liu G, Chen Y, Wu T, Feng F, Sun C. Liu Z, et al. J Lipid Res. 2016 Aug;57(8):1373-81. doi: 10.1194/jlr.M063537. Epub 2016 Jun 17. J Lipid Res. 2016. PMID: 27317762 Free PMC article.
Sirtuin type 1 (Sirt1) and protein kinase B (Akt2) are associated with development of obesity and inflammation, but the molecular mechanisms of Sirt1 and Akt2 interaction on adipose inflammation remain unclear. ...Immunoprecipitation assay demonstrated that RES enha …
Sirtuin type 1 (Sirt1) and protein kinase B (Akt2) are associated with development of obesity and inflammation, but the molecular mec …
Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma.
Kim KW, Kim JY, Qiao J, Clark RA, Powers CM, Correa H, Chung DH. Kim KW, et al. Oncotarget. 2019 Sep 24;10(54):5645-5659. doi: 10.18632/oncotarget.27210. eCollection 2019 Sep 24. Oncotarget. 2019. PMID: 31608140 Free PMC article.
Here we hypothesize that targeting AKT2 could block the signal transduction pathways enhanced in chemo- and/or radiation-resistant neuroblastoma cancer stem-like cells. We found cell proliferation and survival signaling pathways AKT2/mTOR and MAPK were enhanc …
Here we hypothesize that targeting AKT2 could block the signal transduction pathways enhanced in chemo- and/or radiation-resistant ne …
Role of PI3K, mTOR and Akt2 signalling in hepatic tumorigenesis via the control of PKM2 expression.
Nemazanyy I, Espeillac C, Pende M, Panasyuk G. Nemazanyy I, et al. Biochem Soc Trans. 2013 Aug;41(4):917-22. doi: 10.1042/BST20130034. Biochem Soc Trans. 2013. PMID: 23863156
In the present article, we discuss the requirement of different PI3K/mTOR downstream effectors for the metabolic adaptation in liver cancer cells driven by this signalling pathway. We provide evidence for a selective involvement of the mTOR target Akt2 in tum …
In the present article, we discuss the requirement of different PI3K/mTOR downstream effectors for the metabolic adaptation in liver …
The role of the mTOR pathway during liver regeneration and tumorigenesis.
Panasyuk G, Patitucci C, Espeillac C, Pende M. Panasyuk G, et al. Ann Endocrinol (Paris). 2013 May;74(2):121-2. doi: 10.1016/j.ando.2013.03.003. Epub 2013 Apr 6. Ann Endocrinol (Paris). 2013. PMID: 23566619 Review.
Our team is focused on the role of mammalian Target of Rapamycin (mTOR) in two pathophysiological conditions that modulate liver growth: liver regeneration after partial hepatectomy, and steatosis-associated tumorigenesis. Target kinases of mTOR seem more specifical …
Our team is focused on the role of mammalian Target of Rapamycin (mTOR) in two pathophysiological conditions that modulate liver grow …
220 results