Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice.
Sasako T, Umehara T, Soeda K, Kaneko K, Suzuki M, Kobayashi N, Okazaki Y, Tamura-Nakano M, Chiba T, Accili D, Kahn CR, Noda T, Asahara H, Yamauchi T, Kadowaki T, Ueki K.
Sasako T, et al.
Nat Commun. 2022 Oct 5;13(1):5655. doi: 10.1038/s41467-022-33008-2.
Nat Commun. 2022.
PMID: 36198696
Free PMC article.
These phenotypes are almost reversed by additional knocking out of Foxo1/4, but only partially by additional knocking out of Tsc2 to activate the mTOR pathway. Overall, our data suggest that, unlike in lower organisms, suppression of Akt activity in skeletal muscle of mamm …
These phenotypes are almost reversed by additional knocking out of Foxo1/4, but only partially by additional knocking out of Tsc2 to activat …